The future of Cancer Screening and Diagnosis

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PARE approach
The biggest fear after regression of a tumor is of its recurrence. A new cancer test can tell whether and when a tumor is recurring after initial treatment.

The test is based on the sample of the original tumor to identify it's cancer gene sequences which are unique. Later blood tests are used to look for that genetic signature and find out if surgeons have successfully removed the entire tumor, or if the cancer has metastasized or whether it is recurring.

The test has been discovered by a team of Johns Hopkins researchers led by Victor E. Velculescu, MD, PhD.

Researchers found that cancer chromosomes were jumbled, so they looked for larger pieces of the DNA in the tumor. Each patient's tumor has nine characteristic rearrangements at the ends of its chromosomes that form the tumor's unique fingerprint. So the team called the tool `PARE' -- personalized analysis of rearranged ends.

"The PARE approach could be used to develop biomarkers for virtually any cancer," Velculescu said.

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User Comments

06 February, 2011 | Preethi Rahul | Reply

Hi Poonam.. indeed a commendable article... Preventive oncology is definitely the need of the hour as far as the indian society is concerned..a lot of money is being spent on clinical trials and drug development.. but cancer is a disease if detected at a very early stage can be treated easily.. Thus the media needs to spread more awareness on preventive oncology.. more people should be encouraged to go for screening tests.In fact free screening should be done in rural areas for cancers related to tobacco. It is good to know about the latest techniques ..only the cost becomes an issue in a developing nation like India

07 February, 2011 | Poonam | Reply

Thank You Preethi. Inspite of sophisticated techniques being available for screening, a lack of awareness and a fear of getting a positive diagnosis often come in way of early diagnosis. Cancer is a silent disease in the very early stages and patients usually report to the physician only during advanced stages of the disease. If high risk individuals would voluntarily get themselves screened a lot of lives could be saved.

02 February, 2011 | Vijayalakshmi Iyengar | Reply

Its indeed commendable that latest studies are getting more sophisticated in their treatment- painless and more accurate as they are targeted exclusively on cancer cells, sparing the healthy cells from being affected.
However we as a society should focus and promote HEALTHY EATING, for as the adage goes `An ounce of prevention is better than a pound of cure', besides we definitely have quality of life and we are sure of the end result

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Tags: Cancer, Cancer Diet & Nutrition, Cancer Management, Cancer Prevention, Lung Cancer, Oral Cancer, Screening

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