Causes of Gout
When urate crystals (caused by a high amount of uric acid in the blood) accumulate in the synovial fluid around the joints it causes inflammation and acute pain. As body cells divide and multiply, the body breaks down purines and uses its components. Purines are also present in many foods.
Under normal circumstances, the kidneys excrete the purine in the form of uric acid in urine. But sometimes the body produces too much uric acid (hyperuricemia) or the kidneys throw out too little uric acid. When this happens, uric acid can build up in the form of sharp needle like crystals, in a joint or in the tissue around it. When the immune system attacks these crystals, it leads to pain, inflammation and swelling.
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