Now the question is `what is the criterion that decides whether the stem cell should become a bone cell or fat cell? According to researcher Dr Janet Rubin, professor of medicine at the University of North Carolina, all mesenchymal stem cells of the bone marrow could become fat cells by default. However mechanical signals both of low intensity and high intensity reduce fat and build bone which would directly affect the marrow stem cells and nudge them in that direction. Her experiments on bone marrow of mice showed that if she bathed the cells in excess insulin and other elements, they smoothly differentiated into fat cells but if she stimulated them with mechanical vibrations indicative or representative of exercising, all of them did not become fat cells.
In her earlier experiments Dr Rubin had used high magnitude mechanical vibrations and the results were lower number of fat cells, however in the current study she found that even with vibrations of a lower magnitude and one that favoured a fat inducing environment she was able to pull off lower number of fat cells. However it appeared that the biochemical signalling in the dual or multiple dose stimulation of stem cells were more complex. The findings were indicatively thought provoking but not wholly conclusive and a few similar studies could firmly establish the same.
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