The future of diabetes treatment - with advances in research.

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Replacing needles soon? Insulin dependent diabetics are dependent on regular daily injections to manage their disease. This can be very inconvenient. So far, oral insulin pills have not been successful because the delicate insulin proteins get destroyed by digestive enzymes.

MonoSolRx.Inc a company is in the quest for effective oral insulin. The company which develops edible film, about the size, shape and thickness of a postage stamp is in the process of developing an insulin-impregnated film that can be placed against the inside of the cheek that dissolves, passing insulin directly into the circulatory system. The insulin film has worked well in monkeys, and the company plans to begin human trials in Europe shortly.

The success of this technology will simplify life for insulin dependent diabetics.

Converting Type 1 diabetes through hormone therapy – A recent research by UT Southwestern Medical Center showed that Type 1 diabetes can be converted to an asymptomatic, non-insulin-dependent disorder by altering the actions of a specific hormone. Findings in mice reveal that insulin becomes completely superfluous and its absence does not lead to diabetes when the actions of glucagon are suppressed. Glucagon is a hormone produced by the pancreas which prevents low blood sugar. It causes high blood sugar in people with type 1 diabetes.

Dr. Roger Unger, professor of internal medicine and senior author of the study appearing online and in the February issue of Diabetes says, “If diabetes is defined as restoration of glucose homeostasis to normal, then this treatment can perhaps be considered very close to a 'cure.' "
If these latest findings work successfully, injected insulin will no longer be necessary for people with type 1 diabetes.

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User Comments

01 May, 2012 | Samantha | Reply

There is limited prognosis in the future of Diabetes treatment unless there is addition of an intensive lifestyle intervention especially in children.
According to David Allen, MD, from the Department of Pediatrics at the University of Wisconsin School of Medicine and Public Health in Madison, writes that 50 years ago children did not need to make healthy choices to avoid obesity because "they simply lived in an environment that provided fewer calories and included more physical activity for all. Any illness from childhood overnutrition is a societal and cultural problem that current medicines treat, but they cannot "stave off a lifetime of illness".

13 December, 2011 | Vidya Yadav | Reply

An Ultra-Low-Calorie, Low-Carb Diet is Sufficient to Reverse Type 2 Diabetes?
According to a ground breaking British study with just 11 patients on a restricted super-low-calorie diet with just diet drinks and non-starchy vegetables. On completion of 8 weeks the researchers monitored the fat content in the liver and the insulin production from the pancreas and compared to a control group of non-diabetics.
According to the researchers after just a week, the Fasting blood sugar levels were normal, MRI scans of the patients’ pancreases revealed that fat levels had dropped, which allowed the organ to produce more insulin.
The researchers felt that though the results were promising it was a very small study, but held promise that with proper management Diabetes could be reversed and also cautioned that diabetic patients should not undertake such a drastic dietary change without medical supervision.

21 November, 2011 | Shipra | Reply

an interesting article in Science Digest - Although daily injections of insulin would still be needed, inhaled insulin is currently in clinical trials and may be headed for a fast track approval by the Food and Drug Administration (FDA). These inhalers are about the size of a flashlight and uses rapid-acting insulin. The sprayed insulin is inhaled into the mouth and coats the mouth, throat and tongue. The insulin passes quickly into the bloodstream.

16 November, 2011 | Vijayalakshmi Iyengar | Reply

Could this be yet another exciting finding in diabetes research? Researchers at Albert Einstein School of Medicine in New York with the confirmation that the brain plays a role in glucose production in the liver, feel that this may now lead to new ways to treat diabetes by targeting the brain and the central nervous system instead of the pancreas.

According to study lead, Preeti Kishore, there may be a possibility of treating diabetes by restoring normal blood sugar regulation by targeting the potassium channels in the brain. This discovery could lead to new diabetes treatments with drugs that target the brain and central nervous system instead of the pancreas. Further studies are required, as the research is still ongoing.

16 November, 2011 | Priya Yadav | Reply

Before Human insulin was manufactured, insulin derived from pigs and cows was used to treat diabetics. Scientists at the Washington University School of Medicine in St. Louis are conducting experiments to find out if they can transfer pancreatic cells from pigs that would manufacture insulin in humans.Testing in humans is in the planning stages.
The advantage they see is in this method is that transplantation of the cells may not require any immune suppression (anti-rejection) drugs, typically required with the transplantation of whole organs and these drugs cause a lifetime of side effects and complications.

16 November, 2011 | Vijayalakshmi Iyengar | Reply

Despite the fact that scientists are constantly trying to develop new approaches to diabetes treatment, we dietitians at NV support the view held by ADA (American Diabetes Association) in that prevention — with lifestyle changes in diet, activity and attitude -is the best way to tackle this growing health care problem.

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